When the rotational barriers are very high the atropisomers can be resolved using chiral HPLC columns.
The development of new compounds with axial chirality has become an interesting research field for the development of enantiopure molecules without canonical stereogenic carbons. Atropisomers due to C-C, C-N and C-B bonds have been studied.
When the rotational barriers are very high the atropisomeric pairs can be resolved using chiral HPLC columns.
DFT calculations associated with chiro-optical methods (ECD and VCD) can provide the absolute configuration of organic molecules when the X-Ray anomalous dispersion method is not applicable.
